Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
48, Number 1, January 2010, pp. 29-34
Titanium-Coated Silica Spheres Prepared by Self-Assembly
Technique for Use as HPLC Packing
Jin Ge1,2, Liang Zhao1, Li-Ren Chen1,
and Yan-Ping Shi1,
1Key Laboratory for Natural Medicine of Gansu Province, Lanzhou
Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou
730000, China;
2Graduate School of Chinese Academy of Sciences, Beijing
100039, China
Titania-coated silica spheres were prepared by
a layer-by-layer self-assembly technique for use as a high-performance
liquid chromatography packing. This packing has a high surface
area of 202.1 m2/g, a large pore volume of 0.36 cm3/g,
and a pore diameter of 7.0 nm. Furthermore, the packing particles
exhibit narrow pore size distribution and good pore structure.
The chromatographic behavior of the packing was studied under
both normal and reversed-phase conditions. Low column pressures
were observed. Aromatic isomeric compounds were well separated
on the TiO2/SiO2 column under normal
phase conditions; pyridine and aniline derivatives were separated
on the octadecyl–bonded TiO2/SiO2 (ODT)
column, respectively, under reversed-phase conditions, and highly
symmetrical peaks were obtained for 15 basic compounds. The chemical
stability of the stationary phase was tested with sodium phosphate
solution (10 mmol/L, pH = 10) at 25°C and potassium phosphate
solution (50 mmol/L, pH = 10) at 50°C.
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