Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 5, May/June 2009, pp. 392-395
Effects of Ionic Liquid on the Separation of
2-Chlorophenol and 2,4,6-Trichlorophenol in RP-HPLC
J. Zheng and K.H. Row
Center for Advanced Bioseparation Technology, Department of Chemical
Engineering, Inha University, Incheon 402-751, South Korea
In this study, the use of ionic liquids as additives
in the separation of 2-chlorophenol and 2,4,6-trichlorophenol
in reversed-phase high-performance liquid chromatography is reported.
The ionic liquids used were 1-butyl-3-methylimidazolium tetrafluoroborate,
1-ethyl-3-methylimidazolium tetrafluoroborate, 1-ethyl-3-methylimidazolium
methylsulfate ([EMIm][MS]), and 1-octyl-3-methylimidazolium methylsulfate
([OMIm][MS]), because of their high hydrophobicity and good solvating
properties. The effects of the ionic liquid on retention factor
and resolution, and the change of detector response using the
different ionic liquids were studied. Separation with the [MS]
anion ionic liquid in the eluent resulted in better resolution
than with the [BF4] anion ionic liquid. The best result
was achieved using 3.0 mM/L of [OMIm][MS] and 1.0 mM/L [EMIm][MS]
as mobile phase additives.
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