Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 6, July 2009, pp. 432-442
Monolithic Silica Stationary Phases in Liquid
Chromatography
Imran Ali1, Vinay D. Gaitonde2,
and Hassan Y. Aboul-Enein3, 1Department of Chemistry, Jamia Millia Islamia (Central University),
New Delhi – 110025, India; 2Prochrome India, A/2,Varsha
Milan, Sahar Road, Andheri East, Mumbai – 400999, India;
and 3Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical
and Drug Industries Research Division, National Research Centre,
Dokki, Cairo 12311, Egypt
During the last few decades, monolithic stationary
phases (based on silica and polymers) have been used for fast
separations in high-performance liquid chromatography (HPLC)
and capillary electro-chromatography (CEC). The present article
describes the preparation, properties, and applications of these
stationary phases. Attempts have been made to discuss the preparation
of reversed-phase monolithic HPLC columns and CEC capillaries.
The chromatographic properties of these phases have been described.
The applications included their use in HPLC and CEC modalities
of liquid chromatography. The optimization of separations of
various molecules on these phases has been discussed. Efforts
were also made to predict the future perspectives of monolithic
stationary phases.
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