Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 6, July 2009, pp. 407-417
Monolithic Stationary Phases in Classic and Chiral
Pharmaceutical Analysis with CEC and pCEC
Indiana Tanret, Debby Mangelings, and Yvan Vander
Heyden
Department of Analytical Chemistry and Pharmaceutical Technology,
Pharmaceutical Institute, Vrije Universiteit Brussel-VUB, Laarbeeklaan
103, B-1090 Brussels, Belgium
New stationary phases play an important role in
the evolution of separation methods. The use of monolithic phases
in capillary columns has become rather widespread. The ease of
their preparation, their versatility, and the abundance of available
chemistries increase their attractiveness, even dethroning the
particulate phases. This review paper overviews the different
types of monoliths used in capillary electrochromatography and
pressurized capillary electrochromatography for the enantiomeric
separation of chiral molecules and the analysis of pharmaceutically
relevant molecules. The diverse methods of monolith preparation
as well as the different types of used materials are discussed,
as well as the ways they can be modified to fulfill given analysis
needs (e.g., selectivity, efficiency of separation, speed of
analysis, and economical interest). In addition, some of the
advantages and drawbacks of the different monolithic materials
are mentioned.
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