Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 1, January 2009, pp. 67-74
Determination of Ten Haloacetic Acids in Drinking
Water Using High-Performance and Ultra-Performance Liquid Chromatography–Tandem
Mass Spectrometry
Chia-Yang Chen1, Shueh-Ni Chang1,
and Gen-Shuh Wang1,2 1Institute of Environmental Health, College of Public Health,
National Taiwan University, Taipei 10055, Taiwan and 2Department
of Public Health, College of Public Health, National Taiwan University,
Taipei 10055, Taiwan
Haloacetic acids (HAAs) are a class of byproducts
resulting from the reaction of chlorinated disinfectants with
natural organic matter. These chemicals have been found in animal
studies to possibly influence hepatic, reproductive, and developmental
functions, and they may be mutagenic and carcinogenic. Because
HAAs are hydrophilic and strongly acidic, it is a challenge to
measure them at low levels. In this study, nine traditional HAAs
and monoiodoacetic acid, an emerging disinfection byproduct,
are analyzed in water directly. HAAs were separated on a BetaMax
Acid column or a HILIC UPLC column, and they were detected by
negative electrospray ionization-tandem mass spectrometry. Although
the on-column limits of detection of HAAs were lower when using
an HILIC UPLC column (0.08–2.73 µg/L) than when using
a BetaMax Acid column (0.18 to 71.5 µg/L), to use an HILIC
UPLC column, it was required to dissolve water samples in 90%
acetonitrile before injection and result in sample dilution.
BetaMax Acid column was found to be more suitable for the analysis
of HAAs in drinking water because there was no need of sample
preparation. Major species of HAAs, such as dichloroacetic acid
and trichloroacetic acid, and other primary species (e.g., dibromoacetic
acid, bromochloroacetic acid and bromodichloroacetic acid) can
be detected using the BetaMax Acid column at concentrations higher
than 1–3 µg/L.
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