Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 1, January 2009, pp. 3-11
Development of a U.S. EPA Drinking Water Method
for the Analysis of Selected Perfluoroalkyl Acids by Solid-Phase
Extraction and LC–MS–MS
Jody A. Shoemaker1, Brenda Boutin2,
and Paul Grimmett1 1U.S. Environmental Protection Agency, Office of Research and
Development, National Exposure Research Laboratory, MS 564, 26
W. Martin Luther King Drive, Cincinnati, OH 45268 and 2National
Council on Aging, c/o U.S. Environmental Protection Agency, Office
of Research and Development, National Exposure Research Laboratory,
MS 564, 26 W. Martin Luther King Dr, Cincinnati, OH 45268
A drinking water method for perfluoroalkyl acids
(PFAAs) is presented that addresses the occurrence monitoring
needs of the U.S. Environmental Protection Agency (EPA) for a
future unregulated contaminant monitoring regulation (UCMR).
This paper describes the challenges associated with developing
an analytical method for 14 PFAAs that will be used for drinking
water occurrence monitoring. The method employs solid-phase extraction
with analysis by liquid chromatography–tandem mass spectrometry
(LC–MS–MS). The final method preservation scheme
requires that samples be stored in polypropylene bottles and
that they be buffered and free chlorine removed with Trizma buffer.
Mean recoveries of chlorinated surface water samples fortified
with the PFAAs at 40–100 ng/L (except for the perfluorooctane-sulfonamido–acetic
acids at 200 ng/L) are 85–112% with < 5% relative standard
deviation. Single laboratory minimum reporting limits of 2.9–14
ng/L are demonstrated with this methodology. The final method
meets all of the EPA UCMR survey requirements for sample collection
and storage, precision, accuracy, and sensitivity and is expected
to be proposed for use under a future UCMR.
Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
This
article is available in its entirety by fax for $40.00.
Visa, MasterCard & Amex accepted.
To
order electronicallyclick here or call: 847-647-2900 ext. 1323 or fax request to: 847-647-1155.
Please
indicate JCS volume and issue along with
page numbers.
For permission to reuse material from Journal of Chromatographic Science, please access www.copyright.com or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of uses.
