Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 4, April 2009, pp. 257-262
Response Surface Optimization for Determination
of Volatile Organic Compounds in Water Samples by Headspace-Gas
Chromatography–Mass Spectrometry Method
Inès Missaoui1, Lotfi Sayedi2,
Bassem Jamoussi3, and Béchir Ben Hassine1 1Faculté des Sciences de Monastir, Laboratoire de Synthèse
Organique Asymétrique et Catalyse Homogène -5019
Monastir, Tunisia; 2Faculté des Sciences de Tunis, Tunisia;
and 3Institut Supérieur de l’Education et de la
Formation Continue, département des sciences physiques,
43 rue de la liberté-2019 le Bardo, Tunisia
The determination of benzene, toluene, p-xylene,
tetrachloroethene, chlorobenzene, and dibromomethane in water
by headspace analysis combined with gas chromatography–mass
spectrometry (HS-GC–MS) has been investigated. An optimization
strategy for the analysis of the six volatile organic compounds
(VOCs) is presented with the experimental design and response
surface methodology aid. Thermostatting time, temperature, and
salt quantity were optimized by using a central composite design,
and quadratic models relating peak areas to the three factors
were built. The mathematical models were tested on a number of
simulated data set and had a coefficient of R2 > 0.98.
The factor effects were visualized as three-dimensional response
surfaces and contour plots. The optimal conditions were achieved
in 36.8 min, at 90°C, and with 6 g of NaCl. The method showed
a good agreement between the experimental data and predictive
values throughout the studied parameter space, and was suitable
for optimization studies of the VOCs in water by the HS-GC–MS
method.
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