Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
47, Number 8, September 2009, pp. 656-669
Evaluation of Automated Stir Bar Sorptive Extraction-Thermal
Desorption-Gas Chromatography Electron Capture Negative Ion Mass
Spectrometry for the Analysis of PBDEs and PBBs in Sheep and
Human Serum
Paul R. Loconto
Division of Chemistry and Toxicology, Bureau of Laboratories,
Michigan Department of Community Health, 3350 North Martin Luther King
Jr. Blvd. P.O. 30035 Lansing, Michigan 48909
Stir-bar sorptive extraction and automated thermal
desorption/cryotrapping interfaced to capillary gas chromatography
and electron capture negative ion mass spectrometry is shown
to effectively isolate and recover polybrominated diphenyl ethers
and polybrominated biphenyls from sheep and human serum. This
paper describes the development of the method and demonstrates
the feasibility of using Twister with spiked serum. Conditions
for conducting stir-bar sorptive extraction and for automated
thermal desorption that led to acceptable analyte recoveries
were optimized. The approach to sample preparation introduced
here significantly reduces tedious labor and solvent consumption
associated with conventional liquid–liquid extraction.
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