Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
46, Number 5, May/June 2008, pp. 454-460
The Overall Quality Control of Radix Scutellariae
by Capillary Electrophoresis Fingerprint
Guoxiang Sun and Cunyi Shi
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang
110016, China.
The qualitative and quantitative analyses are
developed for the overall quality control of Radix Scutellariae,
a Chinese herb, by capillary electrophoresis fingerprint (CEFP).
All experiments are carried out in an uncoated fused silica capillary
(75 cm × 75-µm i.d., effective length 63 cm) with
a 50 mmol/L sodium borate solution (containing 5% acetonitrile,
pH 9.30) under 12 kV. The detection wavelength is set at 280
nm, and naproxen is selected as the referential peak. Some parameters
are used to evaluate the similarities of CEFPs. Eight co-eluting
peaks are selected as the fingerprint peaks of Radix Scutellariae.
The similarities between each of the ten samples and the referential
CEFP of Radix Scutellariae are evaluated both qualitatively
and quantitatively. Determination results indicate that the baicalin
contents from different locations are varied. The methods of
CEFP and quantitative analysis are rapid, simple, and accurate,
with good repeatability, and can be used for the quality control
of Radix Scutellariae.
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