Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
46, Number 5, May/June 2008, pp. 419-423
In Vitro Characterization of Borneol Metabolites
by GC–MS Upon Incubation with Rat Liver Microsomes
Rong Zhang, Chang-hui Liu, Tian-lai Huang, Ning-sheng
Wang, and Sui-qing Mi
Institute of Clinical Pharmacology, Guangzhou University of Chinese
Medicine, Jichang Road 12, Guangzhou 510405, Guangdong Province,
P.R. China
The metabolism of borneol is studied by the analysis
of incubations of in vitro-prepared rat liver microsomes. A sensitive
gas chromatography (GC)–mass spectrometry (MS) method is
developed for the identification of borneol and its metabolites.
Four novel metabolites, which have not previously been reported,
are isolated and confirmed by comparison of the GC–MS method.
The biotransformation pathway of borneol in rat liver microsomes
is proposed based on the in vitro results.
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