Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
46, Number 3, March 2008, pp. 276-287
On-Line Microdialysis Coupled to Analytical Systems
Gui Jin, Qiaoyuan Cheng, Jian Feng, and Fanzhu
Li
Department of Pharmaceutics, Zhejiang Chinese Medical University,
Hangzhou 310053, P.R. China
In vivo sampling of interstitial fluid using microdialysis
(MD) fibers has become a standard and accepted procedure. The
resulting small volume samples, often with low concentrations
of the analyte of interest, present a particular challenge to
analytical methods. Rapid developments of analytical techniques
with high sensitivity accelerate their combination with MD. On-line
MD-based analytical systems are receiving increasing attention
because they can provide near real-time data prior to the off-line
system. The purpose of this review is to provide information
for on-line MD–analytical systems. Special emphasis has
been given to the main progression on methodologies of each method
during recent years. The advantages, limitations, and adaptivity
are also discussed. These methods include on-line MD–liquid
chromatography, on-line MD–capillary electrophoresis, on-line
MD–mass spectrometry, and on-line MD–biosensor.
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