Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
46, Number 7, August 2008, pp. 601-608
Studies of Human and Veterinary Drugs’ Fate
in Environmental Solid Samples—Analytical Problems
Joanna Wilga, Agata Kot-Wasik, and Jacek Namieśnik
Department of Analytical Chemistry, Chemical Faculty, Gdańsk
University of Technology, G. Narutowicza 11/12 Street, 80 – 952
Gdansk
The improvement of medical care worldwide is one
of the reasons for the increasing production of pharmaceutical
products. Human medicines are affordable to a greater proportion
of the world’s population. But a significant amount of
used pharmaceuticals can create problems—accessibility
to high volume production pharmaceuticals contributes to an increased
contamination in the environment and the possibility of adverse
effects on humans and animals. Many of these substances and their
metabolites end up in the soil, sediments, and sludge. Knowledge
regarding the environmental occurrence of pharmaceutical products
is increasing, but information in the peer-reviewed literature
regarding the fate and effects of most pharmaceuticals is limited.
One of the reasons for this lack of data is that, until now,
there have been few analytical methods capable of detecting these
compounds at the low levels, which might be expected in the environment.
This review article covers recent developments in the analysis
of pharmaceuticals in environmental solid matrices (including
soil, sediments, and sludge). We will report applications of
different solid sample extraction methods, and current advances
in liquid chromatography coupled with mass spectrometry for detection
and identification of selected drugs in sludge, soils, manure,
and sediments.
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