Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
46, Number 4, April 2008, pp. 316-319
TLC Analysis of Intermediates Arising During
the Preparation of Oxime HI-6 Dimethanesulfonate
Daniel Jun1,2, Petr Stodulka1,3,
Kamil Kuca1,2,
Vit Koleckar1, Bohuslav Dolezal3, Peter
Simon4, and Miroslav
Veverka5 1Center of Advanced Studies, Faculty of Military Health Sciences,
University of Defence, Hradec Kralove, Czech Republic;
2Department
of Toxicology, Faculty of Military Health Sciences, University
of Defence, Hradec Kralove, Czech Republic; 3Vakos XT a.s., Prague,
Czech Republic; 4Department of Physical Chemistry, Faculty of
Chemical Technology and Food Technology, Slovak University of
Technology, Bratislava, Slovak Republik; and 5Bel/Novamann International
Ltd., Bratislava, Slovak Republik
In this study, several thin-layer chromatography
(TLC) methods are described for the identification of quaternary
and non-quaternary compounds (parent compounds, intermediates,
by-products, and products) arisen within the synthesis of the
acetylcholinesterase reactivator HI-6, at present the most promising
antidote in the case of nerve agent poisonings. Using the TLC
technique, particular E and Z isomers of this compound on the
oxime group are separated. These TLC methods could be of high
interest as quick purity control for those who are interested
in development of new acetylcholinesterase reactivators and the
synthesis of HI-6 in laboratories or in large-scale production.
Reproduction
of editorial content of this journal is prohibited without publisher’s
permission.
This
article is available in its entirety by fax for $40.00.
Visa, MasterCard & Amex accepted.
To
order electronicallyclick here or call: 847-647-2900 ext. 1323 or fax request to: 847-647-1155.
