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Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume 45,
Number 3, March 2007, pp.140-145
Study of Retention Parameters Obtained in RP-TLC
System and Their Application on QSAR/QSPR of Some Alpha Adrenergic
and Imidazoline Receptor Ligands
S. Eri´c, M. Pavlovi´c, G. Popovi´c,
and D. Agbaba
Faculty of Pharmacy, University of Belgrade, P.O. Box 146, Vojvode
Stepe 450, 11000 Belgrade, Serbia and Montenegro
The retention constant (Rm0) is determined for 11
selected adrenergic and imidazoline receptor ligands by reverse-phase-thin
layer chromatography. It is established that the retention behavior
of investigated compounds mostly depends on geometrical, electrostatic,
and hydrogen bonding properties. Good correlations among hydrophobic
parameters Rm0 versus log P for all eleven tested compounds are
obtained. The satisfactory correlations are found between Rm0
versus apparent partition coefficient octanol–buffer pH
7.4 (log P') or apparent partition coefficient in four liposome
systems (log K'M) and hypotensive activity (pC25) for five imidazolines.
The results confirm the suitability of this parameter in quantitative
structure-property and structure-activity relationships studies
of these drugs.
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