Published:Journal of Chromatographic Science,
ISSN 0021-9665 Volume
45, Number 7, August 2007, pp. 439-446
?Validation of Geosmin and 2-Methyl-i-Borneol
Analysis by CLSA–GC–FID Method to Obtain ISO-17025
Accreditation
?J. Romero[1], I. Manero[1], and J. Laso[2]
[1]AGBAR-Aigües de Barcelona. Agbar-tower. Avenida Diagonal,
211, 08018-Barcelona, Spain and
[2]G.S.C.-Gabinete de Servicios
para la Calidad S.A.L.Cocheras 4, 28007-Madrid, Spain
?A study of the accreditation process using closed
loop stripping analysis (CLSA)–gas chromatography (GC)–flame
ionization detection (FID) methodology for the analysis of geosmin
and 2-methyl-i-borneol (MIB) is performed, completing the instrumental
validation process. Quality parameters, such as the linearity
ranges, repeatability and reproducibility, efficiencies, matrix
effects, and interference, are presented. The experimental work
is completed with a study of the associated uncertainty using
a “Bottom-up Approach Method” and a short description
of a control-protocol for preserving the validation conditions
as a method of quality assurance protocol. The results show that
CLSA–GC–FID-MS is a very good tool for the analysis
of geosmin and MIB at a low level threshold, and the working
range obtained is 10–400 ppt (ng/L) for geosmin and 15–400
ppt for MIB, respectively, in both drinking and natural waters.
Uncertainty was approximately 16% for both compounds; good reproducibility
with precision below 10% and bias between 85–90% for the
three matrices considered are obtained.
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