Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume 44,
Number 9, October 2006, pp.574-578
Cardiac Muscle
Sarcolemma Chromatographic Stationary Phase and Its Potential Application
in Drug Screening
Zhi-Qi Zhang[1,2], Xuan-Feng Yue[1], Yan-Ni Zhang[1],
Zhen-Jun Tian[2], and Jian-Xiong Yang[2]
[1]School of Chemistry and Material Science, Shaanxi Normal University, Xi’an,
710062 and
[2]Key Laboratory of Medicinal Plant Resources and Nature Pharmaceutical Chemistry,
Ministry of Education, Shaanxi Normal University, Xi’an, 710062, P.R. China
A new bioactive packing material for liquid
chromatography, sarcolemma chromatography stationary phase
(SCSP), is presented. Its surface characteristics are investigated,
and it is found that the acceptors embedded in sarcolemma remained
bioactive for more than a week. The retention behavior of antagonists
and activators related to cardiac muscle sarcolemma on the
SCSP chromatographic column shows the screening function of
the SCSP column, and the retention behavior of the active components
in the aether extract from the Chinese herb Ligusticum chuanxiong
Hort. on the SCSP column reveals, to a certain extent, the
separation function of the SCSP column. These suggest that
SCSP is a potentially useful material in drug screening.
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