Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
44, Number 4, April 2006, pp. 214-218
Monitoring the Metabolism of Moexipril to Moexiprilat Using High-Performance
Liquid Chromatography– Electrospray Ionization Mass Spectrometry
J. Kóti[1], V. Háda[1], G. Petroianu[2], M.Y.
Hasan[2], K. Tekes[3], Z. Szücs[4], and H. Kalász[2,5],
[1]Spectroscopic Research Division, Gedeon Richter Ltd., Budapest, Hungary;
[2]Department of Pharmacology and Therapeutics, Faculty of Medicine & Health
Sciences, United Arab Emirates University, Al Ain, United Arab Emirates;
[3]Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary;
[4]Research Institute of Medicinal Plants Ltd., Budakalász, Hungary;
and
[5]Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest,
Hungary
High-performance liquid chromatography combined with a UV absorbance
detector and electrospray ionization mass spectrometer is used for the simultaneous
analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat
are determined in samples metabolized by rat and human liver microsomal preparations,
and also in rat urine. The calibration curve is linear in the ng/mL and µg/mL
concentration range of the injected moexipril.
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