Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
44, Number 4, April 2006, pp. 209-213
Improved Real-Time Puff-by-Puff GC–MS System for Whole
Smoke Analysis
C.B. Huang and David A. Self
Philip Morris USA Research Center, 4201 Commerce Road, Richmond, VA 23234
An automated puff-by-puff mainstream smoke (MSS) system is developed
to monitor real-time whole smoke in mainstream cigarette smoke using gas chromatography
(GC)–mass spectrometry (MS). The whole-smoke analysis is based on automated
sample collection and injection into the GC–MS system. The important feature
of this system is the real-time rapid analysis that is simple, sensitive, precise,
flexible, and exhibits low carryover of volatile and semivolatile smoke constituents.
The system is equipped with an automated sampling and switching valve and a
smoking machine. The key improvements of the system, as compared with current
and alternative methodologies, include minimizing variations caused by operator
sampling techniques, the real-time analysis of MSS, the detection of flavorants
in MSS from a single puff of cigarette smoke, the ability to analyze numerous
smoke constituents from either whole smoke or the gas phase of a single puff,
the ability to monitor a few selected smoke constituents in whole smoke using
multiple puffs, and its good feasibility compared with solvent extraction and
impinger trapping procedures for volatile organic compounds in MSS. System configuration
and sampling methodologies are described. Sensitivity, flexibility, precision,
feasibility, carryover, and applications of the system are discussed.
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