Determination of pKa Values by Liquid Chromatography

Published: Journal of Chromatographic Science, ISSN 0021-9665 Volume 41, Number 6, July 2003, pp. 323-326

Markus Manderscheid and Thomas Eichinger*
Aventis Pharma Deutschland GmbH, Drug Innovation & Approval, Frankfurt am Main, Germany

In this paper, we investigate the potential of a high-performance liquid chromatography technique to determine pKa values of drug candidates that show poor solubility in water. The determination of pKa values by this method is in principle not new, but it exhibits simplicity, requires lower quantities of drugs and solvents, and minimal analysis time. The method is an alternative to existing methodology, in which this determination is not readily feasible.

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