Determination of Trace RA by Capillary Electrophoresis– Solid-Phase Microextraction with Direct UV Detection

Published: Journal of Chromatographic Science, ISSN 0021-9665 Volume 41, Number 6, July 2003, pp. 301-304

Mei Fang* and Guowang Xu
National Chromatographic R&A Center of China, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian, 116011, P.R. China

A new method of offline solid-phase microextraction coupled with capillary electrophoresis (CE) [in an uncoated capillary using borax and boric acid in acetonitrile–water (40:60) as the running buffer] with UV detection at 254 nm is presented and used for direct determination of trace biomedically important retinoic acid (RA) without any derivation. As low as 138 ng/mL RA in aqueous solution can be determined using CE with UV detection with a concentration factor of 19.6 times.

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