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Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
41, Number 1, January 2003, pp. 6-9
The Role of Analogue Ions in the Ion-Pair Reversed-Phase Chromatography
of Quaternary Ammonium Compounds
Louis H. Bluhm and Tingyu Li*
Department of Chemistry, Box 351822-B, Vanderbilt University, Nashville, TN
37235-1822
The choice of analogue ion of the mobile phase additive is shown
to significantly affect the analysis of quaternary ammonium compounds (QACs)
in ion-pair reversed-phase high-performance liquid chromatography. A series
of bromide-containing and dodecyl-sulfate-containing mobile phase additives
are investigated using two QAC probe analytes. In all instances, the quaternary-ammonium-containing
mobile phase additives perform better than the corresponding sodium-containing
additives for effective QAC elution. These results indicate that the structure
of the analogue ion, not just its formal charge, is important in the reversed-phase
ion-pair chromatography of these compounds. The relative elution order of the
QAC probe analytes is also influenced by the counter ions of the mobile phase
additives, with bromide and dodecyl sulfate offering opposite elution orders.
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