Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
41, Number 2, February 2003, pp. 100-106
Improvements to EPA Method 531.1 for the Analysis of Carbamates
that Resulted in the Development of U.S. EPA Method 531.2
Margarita V. Bassett[1], Steve C. Wendelken[1], Barry V. Pepich[1],
and David J. Munch[2]
[1]Shaw Environmental, Inc., 26 W. Martin Luther King Drive, Cincinnati, OH
45268 and
[2]U.S. Environmental Protection Agency,
Office of Ground Water and Drinking Water, 26 W. Martin Luther King Drive,
Cincinnati, OH 45268
This project is undertaken to fully optimize the U.S. Environmental
Protection Agency Method 531.1 post-column chemistries and to incorporate recent
advances in liquid chromatographic separation, post-column derivatization,
and detection techniques. Sample preservation and storage stability studies
establish citric acid as a suitable replacement for the caustic monochloroacetic
acid in the current method and confirm its antimicrobial effectiveness. Performance
of an alternate set of commercially available post-column reagents is also
investigated. This research has resulted in the publication of Method 531.2,
a high-performance liquid chromatographic direct injection method for the analysis
of N-methylcarbamoyloximes and N-methylcarbamates using post-column derivatization
and fluorescence detection.
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