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Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 10, October 2001, pp. 190-194
Gas Chromatography–Mass Spectrometry– Single Ion
Monitoring Measurement of 11-Nor-Delta9-Tetrahydrocannabinol-Carboxylic Acid
in Urine
O. Boldis, Gy. Kocsis, A. Gachályi, and J. Fu"rész
Health Protection Institute of the Hungarian Defense Forces, H-1555, Budapest,
P.O. Box 68, Hungary
Gas chromatography combined with mass spectrometry is used to determine the
urinary elimination of 11-nor-Δ9-tetrahydrocannabinol-carboxylic acid.
Single ion monitoring of both 11-nor-Δ9-tetrahydrocannabinol-carboxylic
acid and the internal standard (11-nor-Δ9-tetrahydrocannabinol-carboxylic-D9)
offers selective and sensitive measurement. In order to check the method and
the results, we employ 11-nor-Δ9-tetrahydrocannabinol-carboxylic acid-glucuronide
as an external standard. Our study also demonstrates that the wall of the glass
liner (glass tube) in the injector retards the active compound, which makes
it imperative to replace the glass insert after each run. Otherwise, the value
of the drug measured in subsequent runs will decrease because more of this
compound will adhere to the glass walls.
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