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Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 10, November/December 2002, pp. 581-584
OPLC and HPTLC Methods in Physicochemical Studies of a New Group
of Antimycotic Compounds
Jan K. Rózylo[1], Anna Zabinska[1], Joanna Matysiak[2],
and Andrzej Niewiadomy[2]
[1]Faculty of Chemistry, M. Curie – Sklodowska University, 20-031 Lublin,
Poland and [2]Department of Chemistry, University of Agriculture, 20-950 Lublin,
Poland
In this study two high-performance methods [overpressured layer
chromatography (OPLC) and high-performance thin-layer chromatograpy (HPTLC)
under reversed-phase conditions] are used to evaluate the hydrophobicity properties
of newly synthesized bioactive compounds. The retention behavior of 24 2-(2,4-dihydroxyphenyl)benzothiazoles
are examined for acquisition of log k data. With water–methanol mixtures
as the mobile phases, the concentration range in which the correlation between
log k and methanol content is linear is established for both methods and used
to determine the hydrophobicity parameters of log kW by linear extrapolation.
The effect of substituents on retention constants is quantitated by using the
group contribution parameters (tW). The results suggest the use of OPLC methods
for quick analysis of physicochemical properties of a large number of organic
compounds.
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