Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 10, November/December 2002, pp. 569-574
Correlation between Retention and 1-Octanol-Water Partition Coefficients
of Some Estrane Derivatives in Reversed-Phase Thin-Layer Chromatography
S.M. Petrovic[1], E. Loncar[1], Lj. Kolarov[1], and V. Pejanovic[2]
Department of Analytical Chemistry, Faculty of Technology, University of Novi
Sad, Bul. Cara Lazara[1], P.O. Box 340, 21000 Novi Sad, Yugoslavia and
[2]ICN Galenika, Institute, Batajnicki put b.b., 11000 Zemun, Yugoslavia
The retention constants (RM) of a series of estrane and secoestrane
derivatives are experimentally determined on C18-modified silica gel layers
with methanol–water mobile phases of various concentrations. The slopes
(m) and intercepts (RMW) of the linear relationships between RM and the volume
fraction of methanol are calculated. Both constants increase when the retention
of compounds increases, and there is a linear dependence between them indicating
their additivity; they represent the sums of particular retention contributions
of skeleton and substituents. The contributions, particularly the retention
fragmental constants, are calculated by combining the linear relationships RM/log
P, RM/m, and RMW/log P. The log P values of the compounds and skeleton were
calculated using Rekker’s fragmental constants.
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