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Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 10, November/December 2002, pp. 564-568
Effect of TLC Support Characteristics and Coating on the Lipophilicity
Determination of Phenols and Aniline Derivatives
Tibor Cserháti and Esther Forgács*
Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences,
P.O. Box 17, 1525 Budapest, Hungary
The lipophilicities of 18 ring-substituted phenol and aniline
derivatives are determined on alumina and silica thin-layer chromatographic
supports impregnated with 2.5 and 10% (v/v) paraffin oil in n-hexane using a
mixture of water–methanol as the mobile phases. The effect of calculated
physicochemical parameters and chromatographic conditions on the retention is
elucidated by stepwise regression analyis. It is established that the degree
of impregnation exerts a greater impact on the retention than the character
of the support. Not only the calculated lipophilicity but also various sterical
and polarity parameters significantly influence the retention, indicating the
involvement of factors other than hydrophobic forces in the retention mechanism.
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