Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 5, May/June 2002, pp. 276-291
A Review of Basic Concepts in Comprehensive Two-Dimensional Gas
Chromatography
Ruby C.Y. Ong and Philip
J. Marriott
Centre for Chromatography and Molecular Separations, Royal Melbourne Institute
of Technology, GPO Box 2476V, Melbourne, 3001, Australia
The technique of comprehensive two-dimensional gas chromatography
(GC¥GC) is reviewed. A description of technical aspects of the method illustrates
how the GC¥GC result is achieved through the use of dual-coupled columns
and the modulation of capillary chromatographic peaks. This review presents
an expanded section dealing with the relationship between the modulation phase
and frequency and the resulting peak pulse profiles. Experimental results that
support the appreciation and understanding of the effects that pulsing has on
a chromatographic peak are provided. The main goals of GC¥GC analysis are
discussed with respect to analytical sensitivity and peak capacity arising from
zone compression effects and fast analysis on the second column. A typical application
of GC¥GC is presented, along with a consideration of implementation of the
GC¥GC method.
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