Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 6, July 2002, pp. 326-330
Ion Chromatography Studies of Quaternary Ammonium Halide Solutions
and the Determination of Pharmaceuticals
Lai-Hao
Wang Department of Applied Chemistry, China Nan University of
Pharmacy and Science, Tainan, Taiwan, 71743, R.O.C.
The feasibility of using ion chromatography (IC) in solutions
containing quaternary ammoniums is studied. The results establish the applicability
of IC for the determination of halide ions in a pharmaceutical sample without
interferences by various excipient ions. For IC measurements with suitable methodical
parameters, linearity is maintained over the range of 20 to 200 mg/L and 10.0
to 250 mg/L for the chloride and bromide of quaternary ammoniums, respectively.
A comparison of the anion results obtained from differential pulse voltammetry
shows good agreement.
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