Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 2, February 2002, pp. 97-100
Simultaneous High-Performance Liquid Chromatographic Determination
of Paracetamol, Phenylephrine HCl, and Chlorpheniramine Maleate in Pharmaceutical
Dosage Forms
Hamide çenyuva* and
Tuncel Özden
Instrumental Analysis Centre, Scientific and Technical Research Council of Turkey,
06530, Ankara, Turkey
A rapid, precise, and specific high-performance liquid chromatographic
method is described for the simultaneous determination of paracetamol, phenylephrine
HCl, and chlorpheniramine maleate in combined pharmaceutical dosage forms. The
method involves the use of a µBondapak CN RP analytical column (125 Å,
10 µm, 3.9 x150 mm) at 22°C as the stationary phase with the mixture
of acetonitrile and phosphate buffer (pH 6.22, 78:22) as the mobile phase. Derivatization
of the drugs is not required. The method is applied to commercial pediatric
cough–cold syrups, tablets, and capsules marketed in Turkey. The relative
standard deviation for 10 replicate measurements of each drug in the medicaments
is always less than 2%.
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