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Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 7, August 2002, pp. 383-386
Solvent Effects on the Screening of Parallel Combinatorial Libraries
for Selectors for Chiral Chromatography
Andrew P. Gehring, Louis H. Bluhm, Yufeng Ma, and Tingyu Li*
Department of Chemistry, Box 1822-B, Vanderbilt University, Nashville, TN 37235
The correlation between the resin-swelling property and the outcome
of the crucial equilibration assay used in our parallel library screening method
is investigated. It is found that the incorporation of CHCl3 (an effective swelling
solvent for both the polystyrene and TentaGel resins) into the equilibration
solvent leads to faster equilibration and thus shorter library screening time.
The outcome of the equilibration experiment is also found to depend on the chemical
nature of the solid base resins. It appears that polystyrene resin, which has
a relatively inert surface, provides higher enantioselectivity than the polar
TentaGel resin. The importance of a thoroughly swelled resin for the direct
assay of functional groups on the resin is demonstrated.
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