Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
40, Number 4, April, pp.224-228
Liquid Chromatography in the Analysis of Neurotransmitters and
Alkaloids
I. Baranowska and M. Zydron
Department of Analytical and General Chemistry, Silesian Technical University,
7 Strzody Str., 44-100 Gliwice, Poland
Several thin-layer chromatographic (TLC) and high-performance
liquid chromatographic (HPLC) systems for the determination of biogenic amine
neurotransmitters, alkaloids, and the metabolites of these two groups of compounds
are developed. The possibility of the interference of these compounds is investigated.
In all the systems developed for neurotransmitters, the retention of alkaloids
is examined and vice versa. In TLC because of different visualization procedures
(a dyeing reagent for alkaloids and visible light for neurotransmitters), compounds
of both the groups may be determined simultaneously without the risk of interference.
In HPLC, similarly, the possibility of false diagnosis through simultaneously
employing the fluorimetric and diode-array detectors can be excluded.
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