Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 10, October 2001, pp.
Preparation and Characterization of 3-(Aza-18-Crown-6) Propylsilyl
Bonded Phase for Reversed-Phase Liquid Chromatography
Shi-Lu Da, Yu-Qi Feng, Hui-Ning Da, Yin-Han Gong, and
Yuan-Wei Zhang
39,
Number 5, May 2001, pp. 188-194
Method Development
for the High-Performance Liquid Chromatographic Enantioseparation of 2-Cyanocycloalkanols
G. Török and A. Péter*
Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm
tér 7, H-6720 Szeged, Hungary
E. Forró and F. Fülöp
Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös
utca 6, H-6720 Szeged, Hungary
An
indirect high-performance liquid chromatographic method is developed for the
enantioseparation of cis- and trans-2-cyanocyclopentanol and -cyclohexanol.
The racemic cis-(1S,2S and 1R,2R)- or trans-(1S,2R and 1R,2S)-2-cyanocycloalkanols
are converted to their diastereomers formed with (S)-(+)- or (R)-(–)-a-methoxy-a-(trifluoromethyl)phenylacetyl
chloride. The diastereomers are separated on a reversed-phase column, and the
conditions of derivatization and HPLC analysis are optimized.
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