Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 6, June 2001, pp. 229-234
Behavior
of Haloperidol and Various Phenothiazines on Several Alkyl Bonded PhasesM.
Beljean
CHS Bon Sauveur, 93 rue Caponière, F14000 Caen, France
A.-M. Siouffi*
Faculte des Sciences de St. Jerôme, F13397 Marseille cedex 20, France
Haloperidol and phenothiazines are present in psychiatrical treatments.
An analysis in body fluids is tedious because of the presence of demethylated
(DM) derivatives of phenothiazines. The behavior of some interfering solutes
on alkyl bonded phases has been studied. Phenothiazines and DM derivatives exhibit
a very similar behavior with a binary eluent (phosphate buffer–acetonitrile),
which precludes an optimization with this system. When a ternary phase is used
(phosphate buffer–acetonitrile–methanol), haloperidol and reduced
haloperidol behave differently as compared with phenothiazines. In this mode
it is possible to unambiguously detect haloperidol that would otherwise interfere.
Phenothiazine peaks are characterized by a large tailing. An interesting feature
is the comparison between cyclohexyl bonded and octadecyl bonded phases, the
former being much more efficient.
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