Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 7, July 2001, pp. 293-296
Screening
of Psychotropic Drugs in Human Hair Based on High-Performance Thin-Layer Chromatography
and Microliquid ExtractionT.V.
Polenova, A.G. Borzenko, I.V. Marutsenko, and I.A. Revelsky
Department of Analytical Chemistry, Moscow State University, Russia
The monitoring
of the physiological and functional state of personnel from dangerous industries
is very important for the ensuring of ecological security. Usually, this involves
testing for the consumption of alcohol and drugs of abuse. During the last several
years the use of legal psychotropic drugs has increased and the control over
these drugs has became an actual problem. As is well known, the long-term history
of drugs present in the body is accessible through hair analysis. This is why
the aim of our research is to create a screening procedure based on coupling
high-performance thin-layer chromatography with microliquid extraction as a
psychotropic drug testing method for hair. Some widely distributed antidepressants,
neuroleptics, and sedative drugs are chosen for research. The optimal experimental
conditions for all of the consequent steps for the screening detection of the
model samples are determined. The visual and densitometric detection limits
allow for the employment of the proposed technique for a fast and cost-effective
analysis of the drugs of abuse.
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