Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 1, January 2001, pp. 21-28
Industrial
Scale-Up of Countercurrent Chromatography: Predictive Scale-UpI.A.
Sutherland[1], L. Brown[2], A.S. Graham[5], G.G. Guillon[3], D. Hawes[1], L.
Janaway[1], R. Whiteside[4], and P. Wood[1] [1]Brunel Institute for Bioengineering, Brunel University,
Uxbridge, Middlesex, UB8 3PH, U.K.; [2]AECS, P.O. Box 80, Bridgend, Mid Glamorgan,
CF31 4XZ, U.K.; [3]ENSGTI, University of Pau, rue Jules Ferny, Pau 64000, France;
[4]Chemistry Department, University of Wales Swansea, Singleton Park, Swansea
SA2 8PP, U.K.; and [5]AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire,
SK10 2NA, U.K.
This study describes how scale-up in countercurrent chromatography
(CCC) can be simply predicted on a process scale CCC device by running a preliminary
analytical-sized sample and having knowledge of the stationary-phase retention
at scale-up conditions. Results have shown that simple experimentation can lead
within a day to a process with the capability of several kilograms per day (tons
per year) compound yield, and that this is feasible with benchtop CCC units.
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