Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
39, Number 8, August 2001, pp. 351-356
Multiresidue
Analysis of Fluoroquinolone Antibiotics in Chicken Tissue Using Automated Microdialysis–
Liquid ChromatographysMarilyn
J. Schneider Eastern Regional Research Center, Agricultural Research Service, U.S. Department
of Agriculture, 600 E. Mermaid Lane, Wyndmoor, PA 19038
An
efficient procedure for the simultaneous extraction and analysis of six fluoroquinolone
(FQ) antibiotics is developed using an automated microdialysis–liquid chromatographic
(LC) system. In this method, samples extracted from chicken liver and muscle
are further purified by microdialysis, separated on an LC column, and the FQs
detected by their fluorescence. Recoveries from fortified chicken liver and
muscle samples are at least 70% with limits of quantitation (µg/kg) for
the FQs in liver (and muscle) as follows: 0.3 (0.4) for danofloxacin, 0.8 (0.2)
for desethylene ciprofloxacin, 2 (1) for norfloxacin, 2 (0.8) for enrofloxacin,
3 (1) for ciprofloxacin, and 5 (2) for sarafloxacin. Enrofloxacin and ciprofloxacin
are determined in enrofloxacin-incurred chicken liver and muscle samples using
this method.
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