Study of Surrogates for SW846 Method 8330

Published: Journal of Chromatographic Science, Volume 37, Number 3, March 1999, pp. 65-70.

Study of Surrogates for SW846 Method 8330
Jiefei Ding, Kevin Xie, Eddie Liu, Yongfeng Zhang, Yu-ping Hsia, and Zi-ping Luo

The compounds 1,4-dinitrobenzene (1,4-DNB), 1,2-dinitrobenzene (1,2-DNB), and 3,4-dinitrotoluene are investigated as possible surrogate compounds. Both 1,4-DNB and 1,2-DNB do not coelute with any method target compounds in a C8 column with the specification of 82% water and 18% isopropanol at 1.0 mL/min. Elution conditions using a cyanopropyl (LC–CN) confirmation column are studied for the separation of target analytes and the surrogate compound. Adequate separation on a LC–CN column can also be achieved for the 1,4-DNB and method target analytes using an eluent composed of 55% water, 40% methanol, and 5% acetonitrile at 1.2 mL/min. 1,4-DNB is suitable for use as a surrogate in the Environmental Protection Agency Solid Waste 846 Method 8330. It is shown that utilization of 1,4-DNB as a surrogate compound in Method 8330 analysis improves the defensibility of the data.

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