Published:Journal of Chromatographic Science,
ISSN 0021-9665Volume
37, Number 6, June 1999, pp. 210-214
Rapid Gas Chromatographic
Analysis of Drugs of Forensic InterestTricia A. Williams, Michelle Riddle, Stephen
L. Morgan, and William E. Brewer
High-speed gas chromatographic (GC) screening for drugs of forensic relevance
is performed using a commercial Flash™ GC instrument in which the chromatographic
column is resistively heated at rates of up to 30°C/s. Temperature programming
conditions are varied in an experiment designed to evaluate trade-offs between
resolution and analysis time for a mixture of 19 drugs of abuse. All 19 components
can be separated with excellent resolution in 90 s. Specific analytes can be
analyzed even faster; for example, amphetamine analysis is completed in less
than 20 s. Case studies of confiscated street drugs containing amphetamine,
cocaine, and heroin are analyzed to evaluate the retention time repeatability.
Ten replicate injections over a 2-day period for 3 different drug samples achieved
retention time relative standard deviations in the range of 0.48 to 0.81%.
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