Published: Journal of Chromatographic Science, Volume 36, Number 4, April 1998, pp. 187–190.
Quantitation of Residual N-Methylpyrrolidone
in Losoxantrone Hydrochloride by Reversed-Phase High-Performance
Liquid Chromatography
J.A. Shea, S.C. Cook, W.F.
Shamrock, and J. Segretario
A reversed-phase high-performance liquid chromatographic method designed to quantitate N-methylpyrrolidone (NMP) as a residual solvent in losoxantrone hydrochloride (DuP 941) is described. The experiments performed demonstrate that this procedure can reliably quantitate low concentrations (<0.01%) of NMP in losoxantrone hydrochloride. The sensitivity, linearity, and reproducibility of this method are also demonstrated.
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