Published: Journal of Chromatographic Science, Volume 36, Number 4, April 1998, pp. 175–178.
Highly Sensitive and Specific Assay of
Plasma Melatonin Using High-Performance Liquid Chromatography
with Fluorescence Detection Preceded by Solid-Phase Extraction
E. Kulczykowska and P.M.
Iuvone
This paper describes a new, highly sensitive, rapid method for the determination of low levels of endogenous melatonin, the pineal and retinal hormone, in fish plasma samples. The combination of solid-phase extraction and high-performance liquid chromatography with fluorescence detection significantly improves the separation and increases the sensitivity of the assay. The proposed method may be a useful alternative to previously reported procedures. The assay should be applicable to plasma and tissue samples from other animals, including humans, with only minor modifications.
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