35-5/Rogers.../Chromatographic Profiling as a Tool in the Comparison...

Published: Journal of Chromatographic Science, Volume 35, Number 5, May 1997, pp. 193–200.

Chromatographic Profiling as a Tool in the Comparison and Evaluation of Complex Mixtures
J.C. Rogers, L.S. Winkler, and M.F. Borgerding

Chromatographic profiling, an application in which all peaks in a chromatogram are examined, is useful as a tool for providing comparative information regarding sample composition and chemical complexity. The utility of profiling is demonstrated in two studies that involve complex cigarette smoke matrices. In the first study, profiling reveals that both the vapor phase and particulate phase fractions of mainstream smoke from a cigarette that primarily heats tobacco are reduced in complexity in comparison with control products. Relative to a 1R4F control product, total chromatographic responses (TCRs) for the tobacco-heating cigarette are reduced by 89% in the vapor phase and 70% (93% if major components are excluded) in the particulate phase. The second study focuses on a cigarette that combines two design technologies: an experimental tobacco blend and a new carbon filter. This study shows that the new filter design is primarily responsible for reducing the complexity of the vapor phase fraction of mainstream smoke while having relatively little effect on the particulate phase fraction. Compared with three commercial products, the mainstream smoke vapor phase TCR is reduced by approximately 60%.

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