35-8/Taylor/Trends in SFC: 1997

Published: Journal of Chromatographic Science, Volume 35, Number 8, August 1997, pp. 374–382.

Trends in Supercritical Fluid Chromatography: 1997
L.T. Taylor

The future of supercritical fluid chromatography (SFC) will focus more on the separation of moderately polar analytes with packed columns, modified CO₂, and a host of detectors (e.g., universal, element-specific, and spectrometric). Consequently, SFC will become viewed more like high-performance liquid chromatography (HPLC) and will, in fact, replace HPLC in a number of applications because supercritical fluids have both better mass transport properties than liquids and are less harmful to the environment than commonly used HPLC liquids. The same packed column used for HPLC can, for example, generally be used interchangeably for many SFC applications. The relatively poor solvating power of CO₂, however, has dictated in many cases the use of modifiers in the mobile phase. These additives may enhance the solvating power of the supercritical fluid and deactivate or modify the stationary phase. Packed columns that have much higher decompressed flow rates than open tubular columns will place new demands on the employment of postrestrictor detectors in SFC.

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