Published: Journal of Chromatographic Science, Volume 35, Number 4, April 1997, pp. 156–160.

Optimization of Mobile Phase Conditions for TLC Methods Used in Pharmaceutical Analyses
S.J. Costanzo

A simple empirical procedure is proposed for optimizing thin-layer chromatography mobile phases. This approach is based on an adaptation of the window diagrams technique and requires only a limited amount of data because acceptably accurate intermediate capacity factors and spot width values can be estimated from three initial experiments.

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