Quantitative Determination of Phenols in Mainstream Smoke...

Published: Journal of Chromatographic Science, Volume 34, Number 6, June 1996, pp. 272-275.

Quantitative Determination of Phenols in Mainstream Smoke with Solid-Phase Microextraction–Gas Chromatography–Selected Ion Monitoring Mass Spectrometry
T. Jeffrey Clark and John E. Bunch

A method that uses solid-phase microextraction–gas chromatography–selected ion mode mass spectroscopy has been developed for the quantitative determination of phenolic compounds in cigarette smoke condensate. The concentrations of phenol, o-, m-, and p-cresol, 2-methoxyphenol, 2,6-dimethylphenol, 2,4-dimethylphenol, 2,5-dimethylphenol, 4-ethylphenol, 3-ethylphenol, 2,4,6-trimethylphenol, 4-methoxyphenol, 3-methoxyphenol, vanillin, 1-napthol, and 2-napthol present in Kentucky Reference 2R1F and five commercial cigarette brands are determined. Minimal sample preparation is required, and no organic solvents or derivatization reagents are necessary.

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