Published: Journal of Chromatographic Science, Volume 34, Number 8, August 1996, pp. 368–375.
Comparison of Mass Spectrometric
Ionization Techniques for the Analysis of Some Phenethylamines
A.M.A. Verweij and P.J.L.
Lipman
It is predicted that lower limits of detection can be obtained for some amphetamines—3,4(methylenedioxy)amphetamine (MDA), 3,4-(methylenedioxy)methylamphetamine (MDMA), and 3,4-(methylenedioxy)-N-ethyl amphetamine (MDEA)—with the use of liquid chromatography coupled to mass spectrometry by thermospray, electrospray, and atmospheric pressure chemical ionization interfaces. The lowest detection limits are obtained with the thermospray interface; when a tandem mass spectrometric selected reaction monitoring technique is used in the product ion mode, the limits of detection are in the low picogram range for the amphetamines.
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