Global Optimization of Separation in High- ...

Published: Journal of Chromatographic Science, Volume 34, Number 4, April 1996, pp. 182-184.

Global Optimization of Separation in High-Performance Liquid Chromatography
E.J. Cavalli, C. Guinchard, and R. Moilleron

The statistical technique of optimizing mobile phases for liquid column chromatography using overlapping resolution maps is transformed into a nonstatistical multifactor optimizing method. The optimized parameters are the binary solvent composition, mobile phase flow rate, and analysis time. The main goal is to obtain the fastest analysis compatible with the desired separation. The principle is tested with two different sets of compounds in reversed-phase high-performance liquid chromatography: a mixture of seven herbicides and a mixture of nine benzodiazepines.

Reproduction of editorial content of this journal is prohibited without publisher’s permission.

This article is available in its entirety by fax for $4.00 per page.
Visa or MasterCard accepted.

To order electronically click here
or call: 847-647-2900 ext. 1323
or fax request to: 847-647-1155.

Please indicate JCS volume and issue along with page numbers.