Gas Chromatographic and Mass Spectral Analysis of ...

Published: Journal of Chromatographic Science, Volume 33, Number 4, April 1995, pp. 153-161.

Gas Chromatographic and Mass Spectral Analysis of Methamphetamine Synthesized From Allylbenzene
F. Taylor Noggle, C. Randall Clark, and Jack DeRuiter

The synthesis of methamphetamine from allylbenzene is investigated using gas chromatography–mass spectrometry. Treatment of allylbenzene with HBr yields 1-phenyl-2-bromopropane as a major product. Smaller amounts of 1-phenyl-3-bromopropane, as well as 2,3-, 1,2-, and 1,3-dibromopropane, are also formed during the course of this reaction; both diastereomeric forms of 1,2-dibromopropane are detected in the product mixture. Amination of the crude bromination product with methylamine yields primarily methamphetamine and other amines characteristic of this synthetic method, including the methamphetamine isomer, N-methyl-1-phenyl-1-propanamine.

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